Abstract Lon is a conserved AAA+ (ATPases associated with diverse cellular activities) proteolytic machine that plays a key regulatory role in cells under proteotoxic stress.Lon-mediated proteolysis can be stimulated by either the unfolded or specific protein substrates accumulated under stress conditions.However, the molecular basis for this subst
Abstract One major issue in pharmaceutical pituitary gland in spanish supply chain management is the supply shortage, and determining the root causes of medicine shortages necessitates an in-depth investigation.The concept of risk management is proposed in this study to identify significant risk factors in the pharmaceutical supply chain.Fuzzy fail
Abstract Background In the case of extravasation of radioactive drugs used in peptide-receptor radionuclide therapy of neuroendocrine tumors, or in radionuclide therapy in general, rapid action is important to reduce or avoid complications.The literature on extravasation of drugs for radionuclide therapy is sparse.Based on the present case, we disc
Impulsiveness is a stable personal characteristic that contributes to obesity and may interact with it.Specifically, obesity is caused by unrestrained impulse eating that is not consciously controlled and leads to a hormonal imbalance that also can impair impulse control.However, the mechanism of this cortech sonic-flo gloves relationship is unclea
Abstract Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing antibodies toward highly conserved epitopes in the HA stem.Interestingly, a recent analysis of serum antibody repertoires showed that